You can now import a large file of unsubscribes into your account's unsubscribe list. Previously, you were limited to copying/pasting addresses into your unsubscribe list if you were bringing in data from another e-mail system.
To import a file of unsubscribes, first create a Group under "Groups and E-mail Addresses" and then import the file into that Group. Then use the Group button "Dump Members into Unsubscribe List". This will copy all the e-mail addresses in the Group into your account's unsubscribe list. You can then delete the Group if you like.